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CEPI launches Call for Proposals to Develop Vaccines Against Novel Coronavirus

CEPI launches Call for Proposals to Develop Vaccines Against Novel Coronavirus

 

Deadline: 14 February 2020

CEPI has opened a call for proposals to rapidly develop and manufacture a proven vaccine approach that can be used against novel coronavirus, 2019-nCoV.

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The rapid global spread and unique epidemiological characteristics of 2019-nCoV virus is deeply concerning.

In coordination with WHO, as it leads the development of a coordinated international response, CEPI is promoting the development of new vaccines against the emerging threat of 2019-nCoV virus.

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Objectives

The objective of this Call for Proposals is to rapidly develop and manufacture a proven vaccine approach that can be used against the 2019-nCoV. This call aims to complement CEPI’s 2019-nCoV portfolio and candidates should have large-scale manufacturing capabilities for 2019-nCoV. The organization must be willing to transfer their vaccine technology to a global network of large-scale manufacturing.

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The suggested vaccine-technology performance will be considered towards the following guidelines:

Speed from sequence of pathogen availability to clinical-trial testing
Number of doses needed – to gain clinical benefit
Scale of manufacturing
In the current situation CEPI will be aiming for a capacity of production of millions of doses

Supporting the development of vaccines that can prevent or stop an outbreak is a key part of CEPI’s mission. An equally critical part of the mission is to ensure that the vaccine is available and equally accessible to those who need them. Thus, in addition to the criteria of speed and versatility the vaccine technology must be able to be delivered to individuals easily in an outbreak setting and to be at a cost of goods that does not preclude broad access.

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Eligibility Criteria

The funding opportunity through this Call is open worldwide, to all types of non-profit research organisations, for-profit companies, international organisations and foundations, joint R&D ventures, government research organisations, and academic institutions ideally having a geographical footprint internationally.
Applicants must be legal entities, or consortia comprised of legal entities. At least one of the partners in the applicant organisations or consortia of partnering organisations should have experience in human vaccine development and have a track record of bringing vaccine candidates through to human clinical trials in the past 10 years.
The applicant should also have a manufacturer with a track record of vaccine production identified within the consortium.
To be eligible to submit a proposal the applicant should:
Hold a vaccine technology that has already been proven
Licensed product based on the same technology or
Relevant data from clinical trials of a vaccine candidate based on the same technology
Propose only one 2019-nCoV vaccine candidate per application
Include plans and costs for preclinical studies (toxicology / PoC / challenge / immunotoxicology)
Include plans and costs to conduct Phase I studies
Include parallel plans and costs to generate GMP grade material for Phase II
Indicate final scale-up and include plans, costs, and timelines to generate final manufacturing scale material
Propose how you would accelerate the pathway to licensure of your vaccine candidate
Have the capacity to start vaccine manufacturing in at short notice
Be an organization that must be willing to transfer their vaccine technology to a global network of large-scale manufacturers and ideally has its own large-scale manufacturing capabilities.

How to Apply

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To respond to this Call for Proposals, entities must submit their application to CEPI via a secure portal. Please send an email at the address given on the website. The application should be uploaded in a pdf format. Do not send any additional documents.
The proposal should:
be no longer than 10 pages (excluding references)
include high-level budget (in USD)
be in English

For more information, visit https://cepi.net/news_cepi/cepi-launches-new-call-for-proposals-to-develop-vaccines-against-novel-coronavirus-2019-ncov/

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