Innate Immune Memory Impacting HIV Acquisition and/or Control

Innate Immune Memory Impacting HIV Acquisition and/or Control – US

Deadline: 06-Dec-21

The Department of Health and Human Services (DHHS) and National Institutes of Health (NIH) has announced this Funding Opportunity to investigate innate immune cell effector functions and innate immune memory as a means to prevent HIV infection and/or establishment of disease.

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Exploratory research from basic molecular mechanisms, translational work, and clinical research examining innate memory are encouraged.

Objectives

There is a paucity of data on innate immune memory in general and in the context of HIV specifically.
Addressing this gap is critical to inform and design protective vaccine strategies that will engage, enhance, and extend innate immune cell effector functions without causing harm.
Key scientific questions include:
Does HIV exposure or infection induce innate immune memory?
What mechanisms regulate innate immune memory which impact HIV acquisition?
Can innate memory functions be augmented for more effective HIV vaccination/control strategies?
The primary objective of this funding opportunity is to support exploratory research that will identify basic mechanisms of innate antiviral cell effector functions in the context of HIV, as well as to explore innovative strategies that exploit innate immune cells to prevent acquisition or establishment of HIV infection.
Recent advances in ‘omics’ and EpiTOF/ATAC-Seq technologies, availability of samples from unique human cohorts and clinical studies, and appropriate animal models, could contribute to answering these questions.
Funding Information